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Cat. No.	Product Name	Target	Signaling Pathways
T17103	TM-N1324	Others; GHSR	GPCR/G Protein; Others
	TM-N1324 是一种 GPR39 激动剂。 TM-N1324 在没有和存在 Zn2+ 的情况下分别以 280 nM 和 9 nM 的高效率和效力激活人 GPR39。 TM-N1324 对鼠 GPR39 表现出相似的效力，EC50 分别为 180 nM 和 5 nM。
T4648	TC-G-1008 GPR39-C3	GHSR	GPCR/G Protein
	TC-G-1008 (GPR39-C3) 是一种口服有活性的 GPR39激动剂，可作用于大鼠受体(EC50: 0.4 nM)和人类受体(EC50:0.8 nM)的。
TQ0022	Capromorelin Tartrate 卡普瑞林酒石酸盐,CP 424391-18	GHSR	GPCR/G Protein
	Capromorelin Tartrate (CP 424391-18) 是口服有活性的 growth hormone secretagogue receptor 有效激动剂，能够作用于 hGHS-R1a(Ki:7 nM)。
T16508	PF-5190457 PF-05190457	GHSR	GPCR/G Protein
	PF-5190457 是具有选择性的、有效的生长素释放肽受体选择性的反向激动剂(pKi:8.36)。
T10319	Anamorelin RC-1291,阿拉莫林,ONO-7643	GHSR	GPCR/G Protein
	Anamorelin (ONO-7643) 是新型ghrelin receptor 激动剂，根据FLIPR 检测，得到其EC50=0.74 nM。
T7112	Ibutamoren Mesylate MK-0677,伊布莫仑甲磺酸盐,MK-677	GHSR	GPCR/G Protein
	Ibutamoren Mesylate (MK-0677) 是非肽段类生长激素促分泌素受体 (GHSR) 激动剂，也是一种口服有活性的生长激素 (GH) 促分泌素。
T7225	AnaMorelin hydrochloride RC-1291 hydrochloride,阿拉莫林盐酸盐,ONO-7643 hydrochloride	GHSR	GPCR/G Protein
	AnaMorelin hydrochloride (RC-1291 hydrochloride) 是生长素受体激动剂，根据 FLIPR 检测，得到 EC50=0.74 nM。
T11719	JMV 2959 hydrochloride (925238-89-7 free base) JMV 2959 hydrochloride	GHSR	GPCR/G Protein
	JMV 2959 hydrochloride (925238-89-7 free base) 是一种生长激素促分泌素受体 1a 型 (GHS-R1a) 拮抗剂，在 LLC-PK1 细胞中的 IC50 为 32±3 nM。
T34281	Relamorelin BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131	GHSR	GPCR/G Protein
	Relamorelin (RM-131)是一种具有选择性和有效性的生长素释放肽/生长激素促分泌素受体 (GHSR) 激动剂，是一种有效的生长素释放肽模拟物，对 GHS-1a 受体具有很高的亲和力。Relamorelin 是一种具有中枢渗透性的五肽，可增加生长激素水平，加速胃排空，具有研究恶病质的潜力。
T11798	L-692429 MK-0751	GHSR; GPCR19	GPCR/G Protein
	L-692429 (MK-0751) 是一种有效的非肽基生长激素促分泌素 (GHS) 激动剂，是一种苯并内酰胺的衍生物，可逆转糖皮质激素对 GH 分泌的抑制。L-692429 对 G 蛋白偶联受体 (G protein-coupled receptor)具有很高的亲和力，可用于研究肢端肥大症和肥胖。
T28812	SM-130686 SM 130686,SM130,686,SM 130,686
	SM-130,686 is a potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and growth hormone secretagogue. It has around half the potency of the endogenous agonist ghrelin as a stimulator of growth hormone release.
T31734	BMS-604992 EX1314,EX-1314 HCl,EX-1314,BMS604992,EX-1314 hydrochloride, BMS-604992,EX 1314
	EX-1314 (BMS-604992) is a growth hormone secretagogue receptor (GHSR) agonist.
T28366	PF-04628935 PF 04628935,PF 4628935,PF4628935,PF04628935,PF-4628935
	PF-04628935 is a potent antagonist/inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. PF-04628935 is orally bioavailable and brain penetrant.
T11719L	JMV 2959	Others	Others
	JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).
T76318	GHRF, porcine
	GHRF, porcine 是一种生长激素释放激素 (GHRH) 多肽 (porcine)。GHRF, porcine 与 GHRHR 受体结合并促进生长激素的释放。
T22283	Capromorelin 卡普瑞林,CP 424,391,CP 424391-18	Others	Others
	Capromorelin, a member of the growth hormone secretagogue (GHS) class of drugs, is a ghrelin receptor agonist and a novel therapy for stimulation of appetite in dogs with Ki value of 7 nM for hGHS-R1a and EC50 value of 3 nM for rat pituicyte. Capromorelin
T38959	BMS-604992 dihydrochloride EX-1314 dihydrochloride,BMS-604992 dihydrochloride
	BMS-604992 (EX-1314) dihydrochloride is a selective and orally active small-molecule agonist of the growth hormone secretagogue receptor (GHSR). It exhibits high-affinity binding (k i = 2.3 nM) and potent functional activity (EC 50 = 0.4 nM). Furthermore, BMS-604992 dihydrochloride has been shown to stimulate food intake in rodents.
T40876	BMS-604992 free base BMS-604992 free base,EX-1314 free base
	BMS-604992 (EX-1314) free base is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. It exhibits high-affinity binding (k i = 2.3 nM) and potent functional activity (EC 50 = 0.4 nM). Moreover, BMS-604992 free base has the ability to stimulate food intake in rodents.
T35793	JMV3002 JMV3002
	Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. At 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when test...
T68276	Macimorelin acetate EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate
	Macimorelin (EP-1572) acetate，一种 GH 促分泌素，是一种具有口服活性的GHSR 激动剂。Macimorelin acetate 可刺激 GH 的释放。Macimorelin acetate 可用于成人生长激素缺乏症 (AGHD) 和癌症厌食-恶病质综合征 (CACS) 的研究。
T37412	AZ-GHS-22
	AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1It binds to GHS-R1a with an IC50value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose. 1.McCoull, W., Barton, P., Brown, A.J.H., et al.Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonistsJ. Med. Chem.57(14)6128-6140(2014)
T39236	Relamorelin acetate Relamorelin acetate,RM-131 acetate,BIM-28131acetate
	Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki value of 0.42 nM. Notably, Relamorelin acetate can cross the blood-brain barrier and target the central nervous system. This compound effectively increases growth hormone levels and promotes faster gastric emptying. Due to these properties, Relamorelin acetate holds promise for it...
T75928	des-Gln14-Ghrelin TFA
	des-Gln14-Ghrelin TFA为生长激素促分泌受体的第二个内源性配体。该化合物能在CHO-GHSR62细胞中诱导[Ca2+]I的提升，其EC50值为2.4 nM。
T75262	Relamorelin TFA
	Relamorelin (RM-131) TFA，一种生长素类似物，是一种选择性的生长素释放肽/生长激素促分泌素受体 (GHSR) 激动剂，对GHS-1a 受体的Ki 值为 0.42 nM。Relamorelin TFA 是一种五肽，具有中枢渗透性。Relamorelin TFA 增加生长激素水平，加速胃排空，具有用于恶病质、胃轻瘫和胃/肠运动障碍研究的潜力。

化合物

Cat.No: T17103

Target: Others, GHSR

Cat.No: T4648

Synonym: GPR39-C3

Target: GHSR

Capromorelin Tartrate

Cat.No: TQ0022

Synonym: 卡普瑞林酒石酸盐,CP 424391-18

Target: GHSR

Cat.No: T16508

Synonym: PF-05190457

Target: GHSR

Cat.No: T10319

Synonym: RC-1291,阿拉莫林,ONO-7643

Target: GHSR

Ibutamoren Mesylate

Cat.No: T7112

Synonym: MK-0677,伊布莫仑甲磺酸盐,MK-677

Target: GHSR

AnaMorelin hydrochloride

Cat.No: T7225

Synonym: RC-1291 hydrochloride,阿拉莫林盐酸盐,ONO-7643 hydrochloride

Target: GHSR

JMV 2959 hydrochloride (925238-89-7 free base)

Cat.No: T11719

Synonym: JMV 2959 hydrochloride

Target: GHSR

Cat.No: T34281

Synonym: BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131

Target: GHSR

Cat.No: T11798

Synonym: MK-0751

Target: GHSR, GPCR19

Cat.No: T28812

Synonym: SM 130686,SM130,686,SM 130,686

Cat.No: T31734

Synonym: EX1314,EX-1314 HCl,EX-1314,BMS604992,EX-1314 hydrochloride, BMS-604992,EX 1314

Cat.No: T28366

Synonym: PF 04628935,PF 4628935,PF4628935,PF04628935,PF-4628935

Cat.No: T11719L

Target: Others

Cat.No: T76318

Cat.No: T22283

Synonym: 卡普瑞林,CP 424,391,CP 424391-18

Target: Others

BMS-604992 dihydrochloride

Cat.No: T38959

Synonym: EX-1314 dihydrochloride,BMS-604992 dihydrochloride

BMS-604992 free base

Cat.No: T40876

Synonym: BMS-604992 free base,EX-1314 free base

Cat.No: T35793

Synonym: JMV3002

Macimorelin acetate

Cat.No: T68276

Synonym: EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate

Cat.No: T37412

Relamorelin acetate

Cat.No: T39236

Synonym: Relamorelin acetate,RM-131 acetate,BIM-28131acetate

des-Gln14-Ghrelin TFA

Cat.No: T75928

Relamorelin TFA

Cat.No: T75262

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